Wednesday, 24 May 2023 15:18

Salivary IgA in Patients with Ulcerative Colitis on Different Treatment Modalities Featured

1Talib M. Talib, BDS and 2Taghreed Fadhil Zaidan, PhD
1Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Baghdad, Iraq, 2Department of Dentistry, Al-Turath University College, Baghdad, Iraq.

Corresponding author: Talib M. Talib
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Received 02 February 2023.
Accepted for publication on March 25, 2023.
Published May 24, 2023.

Background Immunoglobulin A (IgA) is the most common immunoglobulin Isotype found on mucosal surfaces, where it serves as the first line of defense against microbial invasion. Objectives The purpose of this study was to compare the levels of salivary IgA in patients with ulcerative colitis (UC) on two different therapeutic modalities to control subjects. Materials and Methods Fifty-three patients (27 male and 26 female) were diagnosed with UC, in the clinics of Gastroenterology and Hepatology Teaching Hospital in Baghdad city through random sampling, twenty five subjects were also recruited as controls with equal age and sex‑matched. All study participants were subjected to intraoral examination to evaluate the oral manifestation. Unstimulated whole saliva was collected under standardized conditions by using the spitting method; the collection is made in the morning from (9-11 a.m.). The collected saliva was centrifuged at 3000 rpm for 10 minutes; the clear supernatant layer was aspirated was stored at -20ºC in deep freeze until analysis. Determination of salivary IgA is done by the Enzyme Link Immunosorbent Assay. Results The present study revealed that the Mean of salivary IgA in patients on Azathioprine monotherapy and Combination therapy ulcerative colitis patients had a statistically non-significant difference as compared to control subjects. Also, the result revealed statistically non-significant differences between monotherapy and combination patient groups. Conclusion In the present study salivary IgA level increased in UC compared to apparently healthy controls and the result showed statistically non-significant differences. Also, the result revealed a statistically non-significant difference between monotherapy and combination therapy patient groups.


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