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Monday, 10 July 2023 15:01

Effect of Vitamin D Deficiency on Remodeling of Periodontal Ligaments after Retention Cession in Rats’ Model

1Asmaa Murshed Khamees, PhD,2Dheaa H. Al Groosh, PhD and 3Noor Abdulkareem Razouki, PhD
1,2Department of Orthodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq.
3Department of Dentistry, Alrafidain University - College, Baghdad, Iraq.
Corresponding author: Asmaa Murshed Khamees
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Received 15 November 2022.
Accepted for publication on February 26, 2023.
Published July 10, 2023.
Doi: https://doi.org/10.58827/451444eujsko


Abstract
Background Application of orthodontic mechanical stress associated with the production of signals that stimulated surrounding cells as well as changes in vascularity of the periodontal tissue and regulate bone resorption and deposition process. Nowadays, vitamin D deficiency (VDD) is one of the major health problems associated with elevation in the ratio of periodontitis and periodontal destruction. Objectives This study aimed to evaluate the histological effect of vitamin D supplementation in VDD on periodontal ligament (PDL) remodeling after orthodontic retention cession in a rat model. Materials and Methods thirty male Waster rats were selected with an age range of 8-10 weeks, divided into a control (C) group (10 rats without intervention) and 20 rats enhanced of vitamin D deficiency feeding diet-free vitamin D for 21 days, then divided into 10 rats of vitamin D deficiency (VDD), and 10 rats vitamin D deficiency and received two doses of vitamin D supplemented at day 1 and 15(VDS) group. All groups received orthodontic active force for 14 days, retention and relapse for 7 days respectively. Histological and histomorphometry evaluated the PDL width remodeling after the retention period. Results PDL borders appear regular in C and VDS groups, while destructive in VDD groups, additionally, a significant increase in the PDL width in VDS followed by C groups and remodeling to the normal width than VDD group Conclusion Vitamin D deficiency may be may be associated with delay in the PDL remodeling that effected retention of teeth after orthodontic treatment

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