1Nazhat Mahmood Abdlkareem Al-Zubaidi, MSc, 2Hussain Owaid Muhammed AL-Obaidi, MSc, and 3Mona N. Al-Terehi, PhD.
1Department of Oral and Maxillofacial Surgery, College of Dentistry, AL-Mustansiriyah University, Baghdad, Iraq. 2Department of Oral Periodontology College of Dentistry, AL-Mustansiriyah University, Baghdad, Iraq. 3Department of Biology. College of Science. University of Babylon, Babil, Iraq.
Corresponding author: Nazhat Mahmood Abdlkareem Al-Zubaidi
Received 06 November 2022.
Accepted for publication on January 23, 2023.
Published September 27, 2023.
Background Oral ulcer (OU) is considered one of the systemic lupus erythematosus (SLE) types, Oral manifestations in different ages: children, adults or older in both genders males and females. Objectives The current investigation aims to associate oral ulcer types with eNOS SNP (rs1799983) genotyping in systemic lupus erythematosus (SLE) types. Materials and Methods The Current research covered 51 SLE with Juvenile JSLE patients of different ages for both sexes which were divided into two subgroups with oral ulcers and without oral ulcers. Genomic DNA extracted from whole blood. Results The results show a high percentage of patients have buccal OU (44.44). A low percentage was observed on the floor and lip (5.55%) respectively. Non-significant associations were found among Thymine- Guanine (TG), Guanine- Guanine (GG) (P= 0.214) and Thymine- Thymine (TT) (P= 0.8292). The allele frequency shows that the G allele was more frequent in SLE with or without OU. The association of rs1799983 genotypes with OU sites shows that TG was more observed in the buccal and palatal in about (66.66). The GG observed in all OU sites, is more frequent in the tongue (66.66%). The TT was observed only in the buccal (16.66%). The pain of OU is not affected by rs1799983 genotyping. Only the TT (10%) was found with the non-painful OU. The oral ulcer number shows that TG was observed in (57.14%) in single OU and (50%) in multiple OU. The GG found low in the multiple OU (37.5%). The TT was found in the multiple OU (12.5%) only. Conclusion The current study didn’t find an association between eNOS in the Single Nucleotide Polymorphism SNP rs1799983 and types of oral ulcers.