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Thursday, 18 April 2024 15:55

Evaluation of Serum Creatine Kinase Level in Hypothyroidism Patients Regarding their Periodontal Condition Featured

1Noor S. Irhayyim, MSc.
1Department of Periodontology, College of Dentistry, Tikrit University, Tikrit, Iraq.
Corresponding Author: Noor Sabah Irhayyim
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Received 22 May, 2023.
Accepted for publication on August 01, 2023.
Published April 15, 2024.
Doi: https://doi.org/10.58827/863068dzeain

Abstract
Introduction Periodontal disease is a chronic inflammatory destructive condition; its target is supporting structures that may lead to the loss of teeth. Hypothyroidism is a condition in which the thyroid gland does not produce and release enough thyroid hormones into the bloodstream which may affect the entire body›s metabolism. Many biomarkers like creatine kinase (CK) have been proposed for early detection of both periodontal disease and hypothyroidism. Objectives The study aimed to assess and make a comparison for the level of serum CK and the status of the periodontium Materials and Methods The 100 participants who chose to be in the study were aged 25-55 years old. They divided into three groups: 50 hypothyroidisms suffering from periodontitis (stage 2 and 3 periodontitis with grade B), 30 patients have periodontitis (stage II and III periodontitis with grade B) that have good general health and no thyroid dysfunction, and 20 participants exhibiting healthy gum condition (clinically healthy periodontium and systemically). The samples of blood were gathered from the subjects for an automated blood analyzer to evaluate the level of CK after the clinical periodontal examination had been completed. Results The result proved that there were highly significant differences among the study and control groups in the clinical periodontal (CAL, BOP score 1, GI, PLI, and PPD). The highest mean values of CK appear in periodontitis (stage II and III grade B) with hypothyroidism (245.32) while the lowest value of the mean of CK shows in the control group (42.13). The correlation of CK with clinical periodontal parameters approximately in three groups revealed a weak positive correlation. Conclusion Evaluating the level of CK in the blood is considered a good biological indicator for anticipating the development of periodontal disease in subjects suffering from thyroid dysfunction, and this gives a good idea about the effect of systemic disease on the periodontal tissues.

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